Hydrochloric Acid → HCID 67469068, 화합물

HRID 1850239노트

반응식

HRID 1850239 반응식
[Br:1][C:2]1[C:3]([CH:8]2[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[ClH:19]>CO>[ClH:19].[NH:10]1[CH2:9][CH:8]([C:3]2[C:2]([Br:1])=[CH:7][CH:6]=[CH:5][N:4]=2)[CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58546913HCID 58546913, 화합물

생성물 1

HCID 67469068HCID 67469068, 화합물수율 108.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl 3-(3-bromopyridin-2-yl)azetidine-1-carboxylate (3) (266 g, 0.849 mol, 1 eq.) in methanol (6 L) was added concentrated HCl (350 mL, 4.2 mol, 4.95 eq.) and the resulting mixture was stirred at RT for 92 hrs. The mixture was concentrated and dried using a rotavapor to obtain 230 g of 2-(azetidin-3-yl)-3-bromopyridine hydrochloride (4).

후처리

  1. concentrationThe mixture was concentrated
  2. customdried

출처 및 근거

ORD 기록
ord-e5017e7ff5b94ccf90111d6ad71d8222
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957073B2

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