4-Bromo-2-chlorotoluene → 1-(3-Chloro-4-methylphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine

HRID 1850443

반응식

HRID 1850443 반응식
Cl.[CH3:2][C:3]1([CH3:21])[CH2:7][C:6]2[C:8]([CH3:20])=[C:9]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:10]([CH3:13])=[C:11]([CH3:12])[C:5]=2[O:4]1.Br[C:23]1[CH:28]=[CH:27][C:26]([CH3:29])=[C:25]([Cl:30])[CH:24]=1>>[Cl:30][C:25]1[CH:24]=[C:23]([N:17]2[CH2:16][CH2:15][N:14]([C:9]3[C:10]([CH3:13])=[C:11]([CH3:12])[C:5]4[O:4][C:3]([CH3:21])([CH3:2])[CH2:7][C:6]=4[C:8]=3[CH3:20])[CH2:19][CH2:18]2)[CH:28]=[CH:27][C:26]=1[CH3:29]

참가 물질

3

반응물 2

HCID 27355544-Bromo-2-chlorotolueneHCID 66759981HCID 66759981, 화합물

생성물 1

HCID 594850151-(3-Chloro-4-methylphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine수율 58%

실험 절차

By using 1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine hydrochloric acid salt (311 mg, 1.00 mmol) synthesized in Reference example 147 and 4-bromo-2-chloro-1-methylbenzene (308 mg, 1.50 mmol), the reaction was carried out in the same manner as Example 23 to obtain the title compound 213 mg (yield 58%).

출처 및 근거

ORD 기록
ord-c5a563e6f3904bdea15fdd2f3b1293e8
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957069B2

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