tert-Butyl (1-isopropylpiperidin-4-yl)carbamate → 1-(Propan-2-yl)piperidin-4-amine

HRID 18506

반응식

HRID 18506 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:9]1)(C)(C)C>CO.Cl>[CH:14]([N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:16])[CH3:15]

참가 물질

4

반응물 1

HCID 20801240tert-Butyl (1-isopropylpiperidin-4-yl)carbamate

생성물 1

HCID 31633331-(Propan-2-yl)piperidin-4-amine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

To 4.8 g (1-Isopropyl-piperidin-4-yl)-carbamic acid tert-butyl ester in 15 mL methanol, 20 mL methanolic hydrochloric acid (8 M) were added and the mixture was stirred for 16 h. Removal of the solvent under reduced pressure, followed by removal of residual volatiles by twice coevaporating with toluene, gave the product. Yield: 5.42 g MS (ES+): m/e=143.

후처리

  1. customRemoval of the solvent under reduced pressure
  2. customfollowed by removal of residual volatiles
  3. customgave the product

출처 및 근거

ORD 기록
ord-6fa2e1b0db5b4502a6fba40fd57bed62
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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