Water → 2-(4-Methoxyphenyl)-2-methylpropan-1-amine

HRID 1850843

반응식

HRID 1850843 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])=[CH:11][CH:10]=1.[OH-].[Na+].O>C(OCC)C>[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:19])([CH3:18])[CH2:16][NH2:17])=[CH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 2191662-(4-Methoxyphenyl)-2-methylpropanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 35813642-(4-Methoxyphenyl)-2-methylpropan-1-amine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
5 °C

실험 절차

A reaction vessel was charged with lithiumaluminium hydride (0.433 g, 11.41 mmol) and dry diethyl ether (20 mL). After cooling to 5° C. a solution of 2-(4-methoxyphenyl)-2-methylpropanenitrile (2.00 g, 11.41 mmol) in dry diethylether (10 mL) was added dropwise. The reaction mixture was stirred at 5° C. for 2 h. The reaction mixture was then cooled in an ice bath and 2N aqueous sodium hydroxide solution (0.8 mL) and water (1.5 mL) were added. After stirring for 20 min additional water (40 mL) was added and the reaction mixture was extracted with ethyl acetate (2×30 mL). The combined extracts were dried (MgSO4) and the solvent was evaporated in vacuo. The crude product (1.94 g, 10.82 mmol) was used without further purification for the next step.

후처리

  1. additionwas added dropwise
  2. temperatureThe reaction mixture was then cooled in an ice bath
  3. additionwas added
  4. extractionthe reaction mixture was extracted with ethyl acetate (2×30 mL)
  5. dry with materialThe combined extracts were dried (MgSO4)
  6. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-b39a970cdb1b44c09f04dc4abd074cba
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957089B2

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