Sodium Hydroxide → HCID 10374990, 화합물

HRID 1851083노트

반응식

HRID 1851083 반응식
[OH-].[Na+].[O:3]=[C:4]1[C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][NH:7][N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12>C(O)C>[O:3]=[C:4]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][NH:7][N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10104421ETHYL 4-OXO-1,4-DIHYDROPYRROLO[1,2-B]PYRIDAZINE-3-CARBOXYLATE

생성물 1

HCID 10374990HCID 10374990, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

2 M sodium hydroxide aqueous solution was added to a suspension of ethyl 4-oxo-1,4-dihydropyrrolo[1,2,b]pyridazin-3-carboxylate in ethanol (165 mL) and stirred overnight at 100° C. The resulting reaction mixture was cooled to room temperature, distilled under reduced pressure, and concentrated. Then, concentrated hydrochloric acid was added until pH decreased to 2. Thereafter, the solid was filtered, washed with water and dried in vacuum. The target compound obtained was subjected to the next step without further purification.

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. distillationdistilled under reduced pressure
  4. concentrationconcentrated
  5. additionThen, concentrated hydrochloric acid was added until pH
  6. filtrationThereafter, the solid was filtered
  7. washwashed with water
  8. customdried in vacuum
  9. customThe target compound obtained
  10. customwas subjected to the next step without further purification

출처 및 근거

ORD 기록
ord-cfe3ec87e500410f9d2862fb23efa607
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957102B2

반응 노트

불러오는 중…