Hydrochloric Acid → HCID 68753946, 화합물

HRID 1851246노트

반응식

HRID 1851246 반응식
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]3)[NH:10][N:9]=2)[CH:5]=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[NH:15]1[CH2:16][CH:13]([C:11]2[NH:10][N:9]=[C:8]([C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=3)[N:12]=2)[CH2:14]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86702386HCID 86702386, 화합물

생성물 1

HCID 68753946HCID 68753946, 화합물수율 76.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

11.6 g (36.8 mmol) tert-Butyl 3-[3-(6-methylpyridine-2-yl)-1H-1,2,4-triazole-5-yl]azetidine-1-carboxylate are dissolved in 150 mL dioxane. 27.6 mL HCl in dioxane (4M) are added dropwise and the reaction mixture is stirred over night at room temperature. The reaction mixture is evaporated to dryness yielding 13.1 g (76.6%) of the desired salt which is 60% pure and is used without further purification.

후처리

  1. customThe reaction mixture is evaporated to dryness

출처 및 근거

ORD 기록
ord-62690b56809448f288d7c43f67ce7d2f
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957064B2

반응 노트

불러오는 중…