Tetrahydrofuran → HCID 178487751, 화합물
반응식
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.C1C[O:18]CC1>[OH-].[Na+].O>[Cl:1][C:2]1[N:11]=[C:10]([OH:18])[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1참가 물질
5
실험 절차
2,4-dichloro-7-methoxyquinazoline (500 mg, 2.183 mmol) was suspended in 2% aqueous NaOH (6 mL). THF (1 mL) was added and the reaction was stirred for 4 h. The reaction was diluted with water and the solid that remained was filtered off. The aqueous phase was diluted with 1 N HCl. The precipitate that formed was filtered, washed with water and dried to give 2-chloro-7-methoxyquinazolin-4-ol (288 mg, 63% yield). MS: MS m/z 211.1 (M++1).
후처리
- filtrationthe solid that remained was filtered off
- additionThe aqueous phase was diluted with 1 N HCl
- customThe precipitate that formed
- filtrationwas filtered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-51fc60faa6634f809e346dcab2e1a2a7
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957203B2
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