Pyrrolidine → HCID 178487759, 화합물
반응식
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>C1COCC1>[CH3:14][O:13][C:6]1[CH:5]=[C:4]2[C:9]([C:10]([OH:12])=[N:11][C:2]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[N:3]2)=[CH:8][CH:7]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
2-chloro-7-methoxyquinazolin-4-ol (165 mg, 0.783 mmol) and pyrrolidine (0.130 mL, 1.567 mmol) were dissolved in THF (2 mL) and heated to 100° C. for 2 h in a sealed tube. The reaction was cooled and the volatiles were removed under vacuum. The crude solid was collected and washed with water, filtered and dried to give 7-methoxy-2-(pyrrolidin-1-yl)quinazolin-4-ol which was carried to the next step without further purification. MS: MS m/z 246.2 (M++1).