Cesium fluoride → HCID 71742701, 화합물
반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:13][CH3:14])[CH:8]=[C:9]([F:12])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.[F-:15].[Cs+]>CS(C)=O.CCOC(C)=O>[F:15][C:2]1[C:11]2[C:6](=[C:7]([O:13][CH3:14])[CH:8]=[C:9]([F:12])[CH:10]=2)[CH:5]=[CH:4][N:3]=1참가 물질
5
반응 조건
- 온도
- 140 °C
실험 절차
To a solution of 1-chloro-7-fluoro-5-methoxyisoquinoline (350 mg, 1.654 mmol) in DMSO (3 mL), was added CsF (502 mg, 3.31 mmol) and the mixture was heated to 140° C. for 4 h. The reaction was diluted with EtOAc and washed with water, and brine. The organic phase was collected, dried over sodium sulfate, and concentrated under vacuum to give 1,7-difluoro-5-methoxyisoquinoline (340 mg, 105% yield) which was not purified further. MS m/z 196.1 (M++1).
후처리
- washwashed with water, and brine
- customThe organic phase was collected
- dry with materialdried over sodium sulfate
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-c10dbc402c364ccd93f8463e129ce2f9
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08957203B2
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