N-bromobutanimide → 4-Bromo-6-methoxyisoquinolin-1(2H)-one

HRID 1852238노트

반응식

HRID 1852238 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[NH:8][CH:7]=[CH:6]2.C1C(=O)N([Br:21])C(=O)C1>C(#N)C>[Br:21][C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[C:9](=[O:13])[NH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 218898546-methoxyisoquinolin-1(2H)-one

생성물 1

HCID 579564624-Bromo-6-methoxyisoquinolin-1(2H)-one수율 55.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 6-methoxyisoquinolin-1(2H)-one (2.5 g, 14.27 mmol) in acetonitrile (10 ml) was added NBS (2.54 g, 14.27 mmol) at room temperature under argon atmosphere. The reaction mass was stirred at the same temperature for 2 h. The precipitated solid was filtered to get crude compound (2 g, 55.2%). The crude compound was taken to the next step without further purification. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.41 (s, 1H), 8.17-8.15 (d, J=8 Hz, 1H), 7.53 (s, 1H), 7.19-7.11 (m, 2H), 3.93 (s, 3H); MS: MS m/z 256.06 (M++2).

후처리

  1. filtrationThe precipitated solid was filtered

출처 및 근거

ORD 기록
ord-0dfb9059130f4c95b49aeca4e9f7041c
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957203B2

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