Heptane → HCID 54684579, 화합물

HRID 1852413노트

반응식

HRID 1852413 반응식
C[N:2]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:3]([C:5]1[C:6](=[O:17])[N:7]([CH3:16])[C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[F:24]C1C=CC(N)=CC=1.CCCCCCC>C1(C)C=CC=CC=1>[F:24][C:21]1[CH:22]=[CH:23][C:18]([NH:2][C:3]([C:5]2[C:6](=[O:17])[N:7]([CH3:16])[C:8]3[C:13]([C:14]=2[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=3)=[O:4])=[CH:19][CH:20]=1

참가 물질

5

반응물 3

HCID 8900HeptaneHCID 97314-FluoroanilineHCID 54676478Roquinimex

생성물 1

HCID 54684579HCID 54684579, 화합물수율 79%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of N-methyl-N-phenyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide (15 mg, 0.050 mmol) and 4-fluoro-aniline (0.100 mmol) in toluene (0.5 mL) was stirred at 100° C. for 1 h. Heptane (1.5 mL) was added and the solution was allowed to cool to room temperature. The crystallized product was separated from the solution and washed with heptane to give the title compound (12 mg, 79%).

후처리

  1. customThe crystallized product was separated from the solution
  2. washwashed with heptane

출처 및 근거

ORD 기록
ord-be9d88eac4554872b56850416c322980
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962598B2

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