Hydrochloric Acid → 3-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)-3-(piperidin-4-yl)propanenitrile
반응식
[C:1]([CH2:3][CH:4]([CH:25]1[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]1)[N:5]1[CH:9]=[C:8]([C:10]2[N:15]3[CH:16]=[CH:17][N:18]=[C:14]3[CH:13]=[C:12]([C:19]3[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=3)[N:11]=2)[CH:7]=[N:6]1)#[N:2].C(Cl)[Cl:39].Cl.O1CCOCC1>>[ClH:39].[CH3:24][N:22]1[CH:23]=[C:19]([C:12]2[N:11]=[C:10]([C:8]3[CH:7]=[N:6][N:5]([CH:4]([CH:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)[CH2:3][C:1]#[N:2])[CH:9]=3)[N:15]3[CH:16]=[CH:17][N:18]=[C:14]3[CH:13]=2)[CH:20]=[N:21]1.[CH3:24][N:22]1[CH:23]=[C:19]([C:12]2[N:11]=[C:10]([C:8]3[CH:7]=[N:6][N:5]([CH:4]([CH:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)[CH2:3][C:1]#[N:2])[CH:9]=3)[N:15]3[CH:16]=[CH:17][N:18]=[C:14]3[CH:13]=2)[CH:20]=[N:21]1참가 물질
6
반응물 4
생성물 2
실험 절차
Tert-butyl 4-(2-cyano-1-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)ethyl)piperidine-1-carboxylate (59.4 mg, 0.118 mmol) was dissolved in DCM (592 μL, 0.118 mmol). To this was added 4N HCl in dioxane (296 μL, 1.18 mmol) and stirred at ambient temperature for 1 hour. Complete conversion was observed after 1 hour and the reaction mixture was concentrated to dryness to afford the HCl salt of 3-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)-3-(piperidin-4-yl)propanenitrile (56.0 mg, 99.7% yield). MS (apci) m/z=402.3 (M+H).
후처리
- waitComplete conversion was observed after 1 hour
- concentrationthe reaction mixture was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-09a3f615c8234a4a8ba681533e67242a
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08962596B2
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