Hydrochloric Acid → HCID 67456826, 화합물

HRID 1852983노트

반응식

[C:1]([CH2:3][C:4]1([N:17]2[CH:21]=[C:20]([C:22]3[N:27]4[CH:28]=[CH:29][N:30]=[C:26]4[CH:25]=[C:24]([C:31]4[CH:32]=[N:33][N:34]([CH3:36])[CH:35]=4)[N:23]=3)[CH:19]=[N:18]2)[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)#[N:2].C(Cl)[Cl:38].Cl.O1CCOCC1>>[ClH:38].[CH3:36][N:34]1[CH:35]=[C:31]([C:24]2[N:23]=[C:22]([C:20]3[CH:19]=[N:18][N:17]([C:4]4([CH2:3][C:1]#[N:2])[CH2:5][CH2:6][NH:7][CH2:8][CH2:9]4)[CH:21]=3)[N:27]3[CH:28]=[CH:29][N:30]=[C:26]3[CH:25]=2)[CH:32]=[N:33]1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 6344Dichloromethane

HCID 312751,4-Dioxane

HCID 53497461Tert-butyl 4-(cyanomethyl)-4-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

생성물 1

HCID 67456826HCID 67456826, 화합물수율 107.8%

실험 절차

Tert-butyl 4-(cyanomethyl)-4-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (Example 21; 17 mg, 0.035 mmol) was dissolved in DCM (170 μL, 0.035 mmol) and treated with 4N HCl in dioxane (170 μL, 0.70 mmol). After 90 minutes, the reaction mixture was concentrated in vacuo to afford 2-(4-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)piperidin-4-yl)acetonitrile hydrochloride (16 mg, 98% yield). MS (apci) m/z=388.3 (M+H).

후처리

concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록: ord-fd748c0d59cf4fd09070ff1f22da56a0
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08962596B2

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