Toluene → Benzimidazole, 2-trichloromethyl-

HRID 18532

반응식

HRID 18532 반응식
[C:1]1([NH2:8])[C:2]([NH2:7])=[CH:3][CH:4]=[CH:5][CH:6]=1.CO[C:11](=N)[C:12]([Cl:15])([Cl:14])[Cl:13].C1(C)C=CC=CC=1>C(O)(=O)C>[Cl:13][C:12]([Cl:15])([Cl:14])[C:11]1[NH:8][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=2[N:7]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 7243O-PhenylenediamineHCID 100479Methyl 2,2,2-trichloroacetimidate

생성물 1

HCID 77133Benzimidazole, 2-trichloromethyl-

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 10 g Benzene-1,2-diamine in 250 mL acetic acid, 22.8 g 2,2,2-Trichloro-acetimidic acid methyl ester were added drop wise at RT. After 2 h 500 mL toluene were added and the solvents were removed under reduced pressure. The residue was codestilled additional two times with toluene. After drying under reduced pressure the product was pure enough for the next reaction step.

후처리

  1. customthe solvents were removed under reduced pressure
  2. customAfter drying under reduced pressure the product
  3. customwas pure enough for the next reaction step

출처 및 근거

ORD 기록
ord-0afa7b3ef23347f6a27ba72298be89b9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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