In a microwave vial was degassed with argon for 15 min. a mixture of 6-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (50 mg, 0.118 mmol), zinc cyanide (14 mg, 0.118 mmol) in dimethylformamide (1.5 ml). Tetrakis(triphenylphosphine)palladium (4 ma, 0.003 mmol) was added and the vial was sealed and heated at 120° C. under microwave irradiation for 10 min. The mixture was diluted with ethyl acetate, washed with a 5% aqueous solution of ammonia, brine and dried over sodium sulfate. The solution was concentrated and purified by flash chromatography over silica gel (cyclohexane/ethyl acetate: 0-20%) to yield 6-cyano-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (33 mg, 76%).
