Ethyl 2-(bicyclo[3.3.1]nonan-9-yl)acetate → 2-(Bicyclo[3.3.1]nonan-9-yl)acetic acid

HRID 1853432노트

반응식

HRID 1853432 반응식
[CH:1]12[CH:9]([CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2>CO.[OH-].[Na+]>[CH:5]12[CH:9]([CH2:10][C:11]([OH:13])=[O:12])[CH:1]([CH2:2][CH2:3][CH2:4]1)[CH2:8][CH2:7][CH2:6]2

참가 물질

4

반응물 1

HCID 68773303Ethyl 2-(bicyclo[3.3.1]nonan-9-yl)acetate

생성물 1

HCID 229236192-(Bicyclo[3.3.1]nonan-9-yl)acetic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of Example 56B (8.5 g 40.4 mmol) in methanol (100 mL), aqueous NaOH (50%, 25 mL) was added. The reaction was stirred at room temperature for 24 hours. Methanol was evaporated and the mixture was extracted with ether and then acidified with 6N HCl to pH 2. The mixture was extracted with ether (2×50 mL), the organic layer was dried with magnesium sulfate, filtered, and concentrated to afford the title compound.

후처리

  1. customMethanol was evaporated
  2. extractionthe mixture was extracted with ether
  3. extractionThe mixture was extracted with ether (2×50 mL)
  4. dry with materialthe organic layer was dried with magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-72d914873ea8410ea1a4165b6d632424
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962639B2

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