Divinyl sulfone → [4-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-carbamic acid tert-butyl ester

HRID 18537

반응식

HRID 18537 반응식
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH:16]([S:18]([CH:21]=[CH2:22])(=[O:20])=[O:19])=[CH2:17]>CCO>[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:22][CH2:21][S:18](=[O:20])(=[O:19])[CH2:16][CH2:17]2)=[CH:12][CH:13]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 6496Divinyl sulfoneHCID 688611tert-Butyl (4-aminophenyl)carbamate

생성물 1

HCID 68616091[4-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-carbamic acid tert-butyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 408 mg (4-Amino-phenyl)-carbamic acid tert-butyl ester and 254 mg Ethenesulfonyl-ethene in 4 mL EtOH were heated for 30 min at 140° C. under microwave irradiation (100 W, CEM Discover™ apparatus). Then, after cooling to RT the solvents were removed under reduced pressure and the residue was dried in vacuo. The crude product was subjected to the next reaction step.

후처리

  1. customwere removed under reduced pressure
  2. customthe residue was dried in vacuo
  3. customThe crude product was subjected to the next reaction step

출처 및 근거

ORD 기록
ord-770f859b938246188dc93593dd1d1dc5
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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