Ammonia → 1-(4-Aminophenyl)piperazin-2-one

HRID 18540노트

반응식

HRID 18540 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]2=[O:16])=[CH:6][CH:5]=1)([O-])=O.N.[H][H]>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]2=[O:16])=[CH:8][CH:9]=1

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 23086769HCID 23086769, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 534061751-(4-Aminophenyl)piperazin-2-one

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매2회

실험 절차

To a solution of 670 mg 1-(4-Nitro-phenyl)-1H-pyrazin-2-one in 100 mL MeOH, 8 g Raney Nickel (washed three times with MeOH) were introduced under a nitrogen atmosphere. Then 10 mL of a 7 M solution of NH3 in MeOH were added. The nitrogen atmosphere was replaced by a hydrogen atmosphere and the mixture was hydrogenated under normal pressure at RT. After 2 h the reaction mixture was filtered through a pad of celite. The solvents were removed under reduced pressure and the residue was subjected to the next reaction step without further purification.

후처리

  1. customwas hydrogenated under normal pressure at RT
  2. filtrationAfter 2 h the reaction mixture was filtered through a pad of celite
  3. customThe solvents were removed under reduced pressure
  4. customthe residue was subjected to the next reaction step without further purification

출처 및 근거

ORD 기록
ord-c83c3cd7ec4f44a284775955b7ce9cbc
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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