Water → 2-(2-Methoxyethoxy)-6-nitroaniline

HRID 18541

반응식

HRID 18541 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:11].Br[CH2:13][CH2:14][O:15][CH3:16].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[CH3:16][O:15][CH2:14][CH2:13][O:11][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[NH2:1]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 41154952-Amino-3-Nitrophenol

생성물 1

HCID 593496042-(2-Methoxyethoxy)-6-nitroaniline

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 5 g 2-Amino-3-nitro-phenol, 4.5 g 1-Bromo-2-methoxy-ethane, 4.4 g K2CO3 in 50 mL DMF were heated to 60° C. for 16 h. Then 50 mL of water were added and the mixture was extracted with ethyl acetate (3×100 ml). The combined organic layers were dried over MgSO4, and the solvents were removed under reduced pressure. The remaining product was pure enough for the next reaction step. Yield: 5.8 g.

후처리

  1. extractionthe mixture was extracted with ethyl acetate (3×100 ml)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. customthe solvents were removed under reduced pressure
  4. customThe remaining product was pure enough for the next reaction step

출처 및 근거

ORD 기록
ord-e4212dad419940b0b09a993a75280f66
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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