Sodium Hydroxide → 3-(2-Methoxyethoxy)benzene-1,2-diamine

HRID 18542

반응식

HRID 18542 반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[C:7]=1[NH2:15].[OH-].[Na+]>C(OCC)(=O)C.C(O)C>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH2:12])[C:7]=1[NH2:15]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 593496042-(2-Methoxyethoxy)-6-nitroaniline

생성물 1

HCID 684142223-(2-Methoxyethoxy)benzene-1,2-diamine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1 g 2-(2-Methoxy-ethoxy)-6-nitro-phenylamine in 10 mL ethyl acetate and 3 mL ethanol, 4.4 g SnCl2 dihydrate were added and the reaction mixture was heated to reflux for 6 h. Then, after cooling 50 mL 2 M NaOH were added and the inorganic precipitate was filtered and washed extensivley with ethyl acetate. The filtrate was extracted with exthyl acetate (3×100 ml), the combined organic layers were dried over MgSO4, and the solvents were removed under reduced pressure. The remaining product was pure enough for the next reaction step.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 6 h
  3. additionwere added
  4. filtrationthe inorganic precipitate was filtered
  5. washwashed extensivley with ethyl acetate
  6. extractionThe filtrate was extracted with exthyl acetate (3×100 ml)
  7. dry with materialthe combined organic layers were dried over MgSO4
  8. customthe solvents were removed under reduced pressure
  9. customThe remaining product was pure enough for the next reaction step

출처 및 근거

ORD 기록
ord-7ca436af06dc497f9fc83b82dd2f06b1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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