Methyl iodide → N,N,N-trimethyl-o-nitrophenylmethanaminium iodide

HRID 1854521

반응식

HRID 1854521 반응식
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-:13])=[O:12])[CH3:3].[I:14][CH3:15]>C(Cl)Cl>[I-:14].[CH3:3][N+:2]([CH3:15])([CH3:1])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 6328Methyl iodide2회HCID 420851N,N-dimethyl-2-nitrobenzylamine

생성물 1

HCID 86676882N,N,N-trimethyl-o-nitrophenylmethanaminium iodide수율 167.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The mixture of 57b (0.18 g, 0.5 mmol) and iodomethane (0.71 g, 5 mmol) in anhydrous CH2Cl2 (5 mL) was stirred for 12 h at r. t., then added additional iodomethane (0.71 g, 5 mmol) and continuously stirred for 12 h. After evaporation, the residue was dispensed with CH2Cl2 and filtered to give 58b (0.27 g, 84%) as yellow solid.

후처리

  1. stirringcontinuously stirred for 12 h
  2. customAfter evaporation
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-71eb6fe81351474fbb2f78ba04d7094d
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962670B2

연결된 노트

불러오는 중…