Sodium Hydroxide → 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid
반응식
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([O:15]CC)=[O:14])[CH:3]=1.[OH-].[Na+]>CCO>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([OH:15])=[O:14])[CH:3]=1참가 물질
4
실험 절차
2 g (8.65 mmol) of ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate are dissolved in 20 ml EtOH and 20 ml of 1M NaOH solution are added. The mixture is stirred overnight, the solvent removed in vacuo and the crude product subject to HPLC chromatography: Yield: 65%
후처리
- customthe solvent removed in vacuo
출처 및 근거
- ORD 기록
- ord-b72cc373c3ff4338887adf24861b0448
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08962671B2
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