Lithium Hydroxide → Quinaldic Acid

HRID 1854804노트

반응식

HRID 1854804 반응식
[OH-].[Li+].[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:13]([O:15]C)=[O:14]>O.CO>[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:13]([OH:15])=[O:14]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 421738methyl quinoline-2-carboxylate

생성물 1

HCID 7124Quinaldic Acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a stirred solution of lithium hydroxide (20.0 mg, 0.84 mmol) in water (1 mL), methyl quinoline-2-carboxylate (20.0 mg, 0.11 mmol) in methanol (3 mL) was added. The solution was left to stir at room temperature for 2 h. The solution was then concentrated in vacuo. The yellow solid residue was dissolved in water and made acidic with concentrated hydrochloric acid. The organic material was extracted with ethyl acetate. The organic layers were dried with anhydrous sodium sulphate, filtered, and concentrated in vacuo to yield quinoline-2-carboxylic acid as a white solid.

후처리

  1. waitThe solution was left
  2. concentrationThe solution was then concentrated in vacuo
  3. dissolutionThe yellow solid residue was dissolved in water
  4. extractionThe organic material was extracted with ethyl acetate
  5. dry with materialThe organic layers were dried with anhydrous sodium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3eb7a72d34414a93be14acdf8931ee1f
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962830B2

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