P-Chloroacetophenone → (2E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 1855371노트

반응식

HRID 1855371 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.C(O[CH:16](N(C)C)[N:17]([CH3:19])[CH3:18])(C)(C)C>>[CH3:16][N:17]([CH:19]=[CH:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:10])[CH3:18]

참가 물질

3

반응물 2

HCID 7467P-ChloroacetophenoneHCID 79885tert-Butoxy bis(dimethylamino)methane

생성물 1

HCID 605938(2E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

실험 절차

1-(4-Chloro-phenyl)-ethanone (49 mg, 0.3 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 28a) to give crude title compound (87 mg) as a yellow solid which was used directly in the next step.

출처 및 근거

ORD 기록
ord-103ea6635fbf426780eaa96478497116
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962834B2

반응 노트

불러오는 중…