(2E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one → [4-(4-Chloro-phenyl)-pyrimidin-2-yl-3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

HRID 1855372

반응식

HRID 1855372 반응식
C[N:2]([CH:4]=[CH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=O)[CH3:3].[N+]([O-])(O)=O.[N+:19]([O-])(O)=O.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([NH:37]C(N)=N)[CH:28]=[CH:29][C:30]=1[N:31]1[CH:35]=[C:34]([CH3:36])[N:33]=[CH:32]1>>[Cl:14][C:11]1[CH:10]=[CH:9][C:8]([C:6]2[CH:5]=[CH:4][N:2]=[C:3]([C:26]3[C:25]([O:24][CH3:23])=[C:30]([N:31]4[CH:35]=[C:34]([CH3:36])[N:33]=[CH:32]4)[CH:29]=[CH:28][C:27]=3[NH2:37])[N:19]=2)=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 605938(2E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 178493228HCID 178493228, 화합물

생성물 1

HCID 131732515[4-(4-Chloro-phenyl)-pyrimidin-2-yl-3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

실험 절차

The title compound was prepared from crude 1-(4-chloro-phenyl)-3-dimethylamino-propenone (87 mg, 0.3 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (83 mg, 0.22 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (29 mg, 33%). Mp 202-204° C.

출처 및 근거

ORD 기록
ord-c58baddf01264b76ab5143bd326eeb10
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962834B2

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