Hydrochloric Acid → 4-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

HRID 1855623노트

반응식

HRID 1855623 반응식
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.FC(F)(F)OC1C=CC(B(O)O)=CC=1.[ClH:34]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:34].[F:1][C:2]([F:18])([F:19])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 214636134-[4-(Trifluoromethoxy)phenyl]benzonitrile

생성물 1

HCID 229284574-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

A solution of 4′-[(trifluoromethyl)oxy]-4-biphenylcarbonitrile (prepared from {4-[(trifluoromethyl)oxy]phenyl}boronic acid by a method analogous to that described for the 4′-trifluoromethyl analogue, Intermediate D6 of WO 02/30911) (66.6 g) in ethanol (2000 ml) and concentrated hydrochloric acid (100 ml) was hydrogenated over Pearlman's catalyst (10 g) at 25 psi until reduction was complete. The catalyst was removed by filtration through celite, then the solvent was removed in vacuo to obtain the desired product.

후처리

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-417e4b42768a406f93aa27a34c23b9a3
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962633B2

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