Trifluoroacetic acid → HCID 178510940, 화합물

HRID 1855661

반응식

HRID 1855661 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C([N:27]1[CH:31]=[C:30]([CH2:32][CH2:33][CH2:34][NH2:35])[N:29]=[CH:28]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)Cl.CCOC(C)=O.O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:27]1[CH:31]=[C:30]([CH2:32][CH2:33][CH2:34][NH2:35])[N:29]=[CH:28]1

참가 물질

6

반응물 2

HCID 6422Trifluoroacetic acidHCID 153458253-(1-trityl-1H-imidazol-4-yl)propan-1-amine

생성물 1

HCID 178510940HCID 178510940, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

2 ml of trifluoroacetic acid are added to 195 mg (0.53 mmol) of 3-(1-trityl-1H-imidazol-4-yl) propylamine dissolved in 8 ml of DCM and then immersed in an ice bath. After warming to room temperature, the reaction medium is stirred for 2 hours and the solvents are then evaporated off. The solid obtained is taken up in EtOAc and water. The aqueous phase is then concentrated and 110 mg of a white powder are obtained and used in the next step without further purification.

후처리

  1. customimmersed in an ice bath
  2. customthe solvents are then evaporated off
  3. customThe solid obtained
  4. concentrationThe aqueous phase is then concentrated

출처 및 근거

ORD 기록
ord-e5f2840a2cd44d209ed34f98dc3dd253
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08962846B2

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