Benzylamine → HCID 23347165, 화합물

HRID 1855959

반응식

HRID 1855959 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH2:14]Br)[CH2:7][OH:8])[CH3:2].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(OCC)(=O)C>CC(C)=O>[CH2:16]([NH:23][CH2:14][CH2:13][O:12][C:11]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[CH:5][C:4]=1[O:3][CH2:1][CH3:2])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 7504BenzylamineHCID 8857Ethyl AcetateHCID 543733553-Ethoxy-4-(2-bromoethoxy)benzyl alcohol

생성물 1

HCID 23347165HCID 23347165, 화합물수율 74.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 27.5 g of 3-ethoxy-4-(2-bromoethoxy)benzyl alcohol and 53.5 g of benzylamine was heated to 130°-135° C. for 1.5 hours with stirring. After cooling the reaction mixture, 300 ml of ethyl acetate was added therein and the mixture was washed twice each time with 50 ml of water, dried with anhydrous sodium sulfate and distilled under reduced pressure to provide an orange oily product. To the product was added 50 ml of acetone to form crystals, which were recovered by filtration under suction to provide 22.5 g of N-benzyl-2-(2-ethoxy-4-hydroxymethylphenoxy)ethylamine having a melting point of 164°-167° C.

후처리

  1. temperaturewas heated to 130°-135° C. for 1.5 hours
  2. additionwas added
  3. washthe mixture was washed twice each time with 50 ml of water
  4. dry with materialdried with anhydrous sodium sulfate
  5. distillationdistilled under reduced pressure
  6. customto provide an orange oily product
  7. customto form crystals, which
  8. filtrationwere recovered by filtration under suction

출처 및 근거

ORD 기록
ord-5c7d3d64f88c419b8bca76ac44892cca
출처 데이터셋
uspto-grants-1980_08
특허 번호
US04217305

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