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Sodium Hydroxide → alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetamide

HRID 1855968
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HRID 1855968 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:20][CH2:21][N:22]([CH:26]([CH3:28])[CH3:27])[CH:23]([CH3:25])[CH3:24])([CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH3:19])[C:9]#[N:10].[OH-:29].[Na+]>S(=O)(=O)(O)O.O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:20][CH2:21][N:22]([CH:23]([CH3:25])[CH3:24])[CH:26]([CH3:28])[CH3:27])([CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH3:19])[C:9]([NH2:10])=[O:29]
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참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 12612248alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetonitrile

생성물 1

HCID 12612308alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetamide

시약·촉매·용매 2

HCID 962Water용매HCID 1118Sulfuric Acid용매

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온도
0 °C

실험 절차

7 Parts of the preceding acetonitrile is dissolved in a solution of 67 parts by volume of concentrated sulfuric acid and 3 parts by volume of water. The resulting solution is heated on a steam bath for about 2 hours and then cooled to about 0° C. and made alkaline by the addition of diluted sodium hydroxide. The alkaline solution is extracted with ether, the ether extract dried over calcium sulfate, stripped of solvent and the residue crystallized from pentane to afford α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-[2-(2-methyl-1-piperidinyl)ethyl]acetamide, melting at about 90°-91° C. This compound has the following structural formula ##STR30##

후처리

  1. temperatureThe resulting solution is heated on a steam bath for about 2 hours
  2. extractionThe alkaline solution is extracted with ether
  3. extractionthe ether extract
  4. dry with materialdried over calcium sulfate
  5. customthe residue crystallized from pentane

출처 및 근거

ORD 기록
ord-ec22c3142b5143fbbd762507474f7ec1
출처 데이터셋
uspto-grants-1980_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04217306

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