Hexane → alpha-(Cyclohexyl)-alpha,alpha-bis[2-(diisopropylamino)ethyl]acetamide

HRID 1855974노트

반응식

HRID 1855974 반응식
[CH:1]([N:4]([CH:26]([CH3:28])[CH3:27])[CH2:5][CH2:6][C:7]([CH2:17][CH2:18][N:19]([CH:23]([CH3:25])[CH3:24])[CH:20]([CH3:22])[CH3:21])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:8]([NH2:10])=[O:9])([CH3:3])[CH3:2].[H][H].CCCCCC>C(O)C.C(Cl)Cl.[Ru](=O)=O>[CH:11]1([C:7]([CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH:26]([CH3:28])[CH3:27])([CH2:17][CH2:18][N:19]([CH:20]([CH3:22])[CH3:21])[CH:23]([CH3:24])[CH3:25])[C:8]([NH2:10])=[O:9])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

참가 물질

7

반응물 3

HCID 8058HexaneHCID 12612273alpha,alpha-Bis[2-(diisopropylamino)ethyl]-alpha-phenylacetamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 23347231alpha-(Cyclohexyl)-alpha,alpha-bis[2-(diisopropylamino)ethyl]acetamide

시약·촉매·용매 3

HCID 82848Ruthenium dioxide촉매HCID 702Ethanol용매HCID 6344Dichloromethane용매2회

반응 조건

온도
125 °C

실험 절차

10 Parts of α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide is dissolved in 130 parts by volume of ethanol and the solution placed in pressure shaker with 1 part of ruthenium dioxide. Hydrogen is introduced at 1000 psi and the reaction mixture heated at about 125° C. and shaken for about 24 hours. Then, the reaction mixture is cooled to room temperature and filtered. The filtrate is stripped of solvent to give an oil. This oil is dissolved in methylene chloride, then hexane added to the solution, methylene chloride evaporated, and the hexane mixture cooled to give α-(cyclohexyl)-α,α-bis[2-(diisopropylamino)ethyl]acetamide, as a crystal solid melting at about 114°-115° C. This compound has the following structural formula ##STR49##

후처리

  1. temperatureThen, the reaction mixture is cooled to room temperature
  2. filtrationfiltered
  3. customto give an oil
  4. customevaporated
  5. temperaturethe hexane mixture cooled

출처 및 근거

ORD 기록
ord-123a16f7f1c3485f89dc95d12ea3e4ae
출처 데이터셋
uspto-grants-1980_08
특허 번호
US04217306

반응 노트

불러오는 중…