Hydrogen Bromide → 4-(1-ethyl-1H-imidazol-2-yl)phenol
반응식
Cl.[CH2:2]([N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]1[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=1)[CH3:3].Br>C(O)(=O)C>[CH2:2]([N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[CH3:3]참가 물질
4
실험 절차
A mixture of 7 parts of 1-ethyl-2-(4-methoxyphenyl)-1H-imidazole monohydrochloride and 75 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed for 2 hours. The reaction mixture is concentrated and a small amount of water is added to the concentrate. The whole is neutralized with sodium hydrogen carbonate. The precipitated product is filtered off and crystallized from a mixture of ethanol and water, yielding 3.3 parts of 4-(1-ethyl-1H-imidazol-2-yl)phenol.
후처리
- temperaturerefluxed for 2 hours
- concentrationThe reaction mixture is concentrated
- additiona small amount of water is added to the concentrate
- filtrationThe precipitated product is filtered off
- customcrystallized from a mixture of ethanol and water
출처 및 근거
- ORD 기록
- ord-363fc264ff104b7681fc7e505032c450
- 출처 데이터셋
- uspto-grants-1980_08
- 특허 번호
- US04218458
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