Phenol → 4-(1,1-diphenylethyl)phenol

HRID 1856366노트

반응식

HRID 1856366 반응식
[C:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]1([OH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.C(=O)([O-])O.[Na+]>>[C:1]1([C:7]([C:18]2[CH:19]=[CH:20][C:15]([OH:21])=[CH:16][CH:17]=2)([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 4

HCID 996PhenolHCID 6101p-Toluenesulfonic acid2회HCID 107401,1-DiphenylethyleneHCID 516892Sodium Bicarbonate

생성물 1

HCID 2450614-(1,1-diphenylethyl)phenol

실험 절차

1,1-Diphenylethylene and phenol in an excess amount were heated in an oil bath at 140° to 150° C. for 1 hour in the presence of p-toluenesulfonic acid. After being allowed to cool, p-toluenesulfonic acid was neutralized using sodium hydrogencarbonate and the excess phenol was then removed by steam distillation to obtain p-(1,1-diphenylethyl)phenol. The resulting phenol was then subjected to carboxylation by the Kolbe reaction according to the process described in Synthesis Example 1 to obtain Compound (4) which was then converted into the zinc salt by the same process as that described in Synthesis Example 2.

후처리

  1. temperatureto cool
  2. customthe excess phenol was then removed by steam distillation

출처 및 근거

ORD 기록
ord-9a33e9db65c041ca84efa519609bf79b
출처 데이터셋
uspto-grants-1980_08
특허 번호
US04219219

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