Acetic Acid → 2-[5-(4-Chlorophenyl)-1,2-oxazol-3-yl]benzoic acid
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=3[C:15]([O:17]C)=[O:16])[CH:9]=2)=[CH:4][CH:3]=1.Cl.C(O)(=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=3[C:15]([OH:17])=[O:16])[CH:9]=2)=[CH:6][CH:7]=1참가 물질
5
실험 절차
A mixture of 2.8 g of methyl 2-[5-(4-chlorophenyl)-3-isoxazolyl]benzoate, 12 ml of concentrated HCl, and 14 ml of acetic acid was held at reflux for 4 hours, cooled, diluted with water, and filtered to give 2.55 g (95%) of white solid, mp 174°-176° C. Recrystallization of the solid gave 2.18 g of solid, mp 175.5°-177.5° C.
후처리
- temperatureat reflux for 4 hours
- temperaturecooled
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-1371d6828a0e4c0b8c12899626175b57
- 출처 데이터셋
- uspto-grants-1980_08
- 특허 번호
- US04219351
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