Sodium Hydroxide → 6-Ethoxy-4-hydroxy-1,5-naphthyridine-3-carboxylic acid
반응식
[CH2:1]([O:3][C:4]1[N:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]([C:14]([O:16]CC)=[O:15])[C:7]2=[O:19])[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]1[N:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]([C:14]([OH:16])=[O:15])[C:7]2=[O:19])[CH3:2]참가 물질
4
실험 절차
A mixture of ethyl 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate (2.98 g), 1N NaOH (50 mL), and ethanol (10 mL) was heated at reflux for 2 h. The reaction mixture was cooled in an ice bath, acidified, and the resulting precipitate collected, rinsed with water and dried to give 2.42 9 of 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid as a beige solid.
후처리
- temperaturewas heated
- temperatureat reflux for 2 h
- temperatureThe reaction mixture was cooled in an ice bath
- customthe resulting precipitate collected
- washrinsed with water
- customdried
출처 및 근거
- ORD 기록
- ord-42d9363f84b04cb995b0719fe2cf9e89
- 출처 데이터셋
- uspto-grants-2000_11
- 특허 번호
- US06143760
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