Hydrochloric Acid → HCID 54470793, 화합물

HRID 1856908노트

반응식

HRID 1856908 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[NH2:21])[CH:16]=O.Cl>CO>[Cl:12][C:13]1[CH:14]=[C:15]([CH:16]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:18]=[CH:19][C:20]=1[NH2:21]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 2357176-Hydroxy-3-coumaranoneHCID 132977934-Amino-3-chlorobenzaldehyde

생성물 1

HCID 54470793HCID 54470793, 화합물수율 91.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3-chloro-4-aminobenzaldehyde 1.24 g were dissolved in methanol 75 ml, concentrated hydrochloric acid 50 ml was added, and the mixture was refluxed for 1.5 hours. The solution was cooled to room temperature, and precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for five hours under reduced pressure to obtain the desired compound 1.75 g.

후처리

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. customprecipitated crystals
  3. filtrationwere filtered
  4. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for five hours under reduced pressure

출처 및 근거

ORD 기록
ord-fe3ce813370f4afaa58b335c7cf54d54
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143779

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