2-Methylterephthalic acid → N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-methoxycarbonylphenyl)carboxamide

HRID 1857150

반응식

HRID 1857150 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.C[C:24]1[CH:32]=[C:31]([C:33]([OH:35])=[O:34])[CH:30]=[CH:29][C:25]=1[C:26]([OH:28])=O.Cl.[CH2:37](N=C=NCCCN(C)C)C>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:17]=[CH:18][C:19]([NH:22][C:26]([C:25]2[CH:24]=[CH:32][C:31]([C:33]([O:35][CH3:37])=[O:34])=[CH:30][CH:29]=2)=[O:28])=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 2280862-Methylterephthalic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

생성물 1

HCID 22132633N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-methoxycarbonylphenyl)carboxamide수율 64%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (100 mg) and commercially available monomethylterephthalic acid (130 mg) were dissolved in N,N-dimethylformamide (4 ml), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (227 mg) was added, and the admixture was stirred at room temperature for 18 hours. The reaction mixture was then purified in the same manner as described in Example 51 to obtain 99 mg of the title compound (yield: 64%).

후처리

  1. customThe reaction mixture was then purified in the same manner

출처 및 근거

ORD 기록
ord-0087767f0f144aa888556ad8510f7e9c
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

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