Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrophenyl isocyanate → N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrophenyl isocyanate | HCID 76835 | — |
| 반응물 | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea | HCID 11259708 | 34.1% |
반응 단계
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (83 mg) was dissolved in toluene (6 ml) with heat, 3-nitrophenyl isocyanate (384 mg) was added, and the admixture was refluxed with heat for 40 minutes. The resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 44 mg of the title compound (yield: 34%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06143764 |
| 출처 데이터셋 | uspto-grants-2000_11 |
| ORD ID | ord-868e6be7482c4d589574d2c93ceda11a |
| 출처 메모 | uspto-grants-2000_11 |