N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea → N-(3-Aminophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

HRID 1857175

반응식

HRID 1857175 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([N+:32]([O-])=O)[CH:27]=2)=[O:24])=[CH:18][CH:17]=1>CN(C)C=O.C(OCC)(=O)C.[OH-].[Pd+2].[OH-].[C]>[NH2:32][C:28]1[CH:27]=[C:26]([NH:25][C:23]([NH:22][C:19]2[CH:18]=[CH:17][C:16]([O:15][C:6]3[C:5]4[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=4)[N:9]=[CH:8][CH:7]=3)=[CH:21][CH:20]=2)=[O:24])[CH:31]=[CH:30][CH:29]=1

참가 물질

4

반응물 1

HCID 11259708N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea

생성물 1

HCID 22132775N-(3-Aminophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea수율 51%

시약·촉매·용매 2

HCID 178502593HCID 178502593, 화합물촉매HCID 22989253N,N-dimethylformamide ethyl acetate용매

실험 절차

N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea (28 mg) was dissolved in N,N-dimethylformamide/ethyl acetate (5 ml/2.5 ml), 20% palladium hydroxide-carbon (97 mg) was added, and the admixture was stirred at room temperature under hydrogen for 3 hours. The reaction mixture was filtered using Celite, the filtrate was washed with brine and then dried with anhydrous sodium sulfate. The solvent was then removed by reduced-pressure distillation to obtain 13 mg of the title compound (yield: 51%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. washthe filtrate was washed with brine
  3. dry with materialdried with anhydrous sodium sulfate
  4. customThe solvent was then removed by reduced-pressure distillation

출처 및 근거

ORD 기록
ord-805ad1393c7e4bbfb2305e195a563881
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

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