(3-Bromophenyl)acetyl chloride → 2-[2-(3-Bromophenyl)-acetylamino]-4-chloro-5-nitrobenzoic acid methyl ester

HRID 1857613노트

반응식

HRID 1857613 반응식
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([Cl:13])=[CH:6][C:5]=1[NH2:14].[Br:16][C:17]1[CH:18]=[C:19]([CH2:23][C:24](Cl)=[O:25])[CH:20]=[CH:21][CH:22]=1>ClC(Cl)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([Cl:13])=[CH:6][C:5]=1[NH:14][C:24](=[O:25])[CH2:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([Br:16])[CH:18]=1

참가 물질

4

반응물 2

HCID 13486899(3-Bromophenyl)acetyl chlorideHCID 15895692Methyl 2-amino-4-chloro-5-nitrobenzoate

생성물 1

HCID 537529782-[2-(3-Bromophenyl)-acetylamino]-4-chloro-5-nitrobenzoic acid methyl ester

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

To a suspension of 2-amino-4-chloro-5-nitrobenzoic acid methyl ester (Example 9, 780 mg in 10 mL dichloroethane) was added a solution of (3-bromophenyl)acetyl chloride (prepared essentially as described in Example 9, 866 mg in 5 mL dichloroethane) and the mixture heated to reflux on an oil bath. After 18 hours, the reaction mixture was concentrated in vacuo and the title compound obtained by crystallization from methanol (1.18 g).

후처리

  1. customprepared essentially
  2. temperatureheated
  3. temperatureto reflux on an oil bath
  4. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-e0de2d9d4b1944f3bfe09d5798f4fb36
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06147088

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