Hydrochloric Acid → (5-(5-Chlorothiophen-2-yl)isoxazol-3-yl)methanamine

HRID 18579

반응식

HRID 18579 반응식
Br[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)[O:5][N:4]=1.C1N2CN3CN(C2)C[N:15]1C3.Cl>CCO>[Cl:13][C:10]1[S:9][C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][NH2:15])[CH:7]=2)=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4101HexamethylenetetramineHCID 111501463-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole

생성물 1

HCID 68616593(5-(5-Chlorothiophen-2-yl)isoxazol-3-yl)methanamine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.00 g (3.59 mmol) 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole and 503.3 mg (3.59 mmol) urotropin were dissolved in 40 mL EtOH. The reaction mixture was stirred at room temperature for 16 h. The next day 3 mL of a conc. HCl-solution were added and the resulting mixture was refluxed for 45 minutes. After cooling the precipitate was filtered off and washed with water. The white crystalline material was dried under reduced pressure at 40° C.

후처리

  1. temperaturethe resulting mixture was refluxed for 45 minutes
  2. temperatureAfter cooling the precipitate
  3. filtrationwas filtered off
  4. washwashed with water
  5. customThe white crystalline material was dried under reduced pressure at 40° C.

출처 및 근거

ORD 기록
ord-5a6c7457cfdb4e10b5a9e271bd261c05
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741341B2

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