Sodium hydride → tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-naphthalen-2-ylmethoxy-5-propyl-piperidine-1-carboxylate

HRID 1858695노트

반응식

HRID 1858695 반응식
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH:15]([CH2:16][CH2:17][CH3:18])[CH2:14][N:13]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:12][CH:11]2[OH:26])=[CH:6][CH:5]=1.Br[CH2:28][C:29]1[CH:38]=[CH:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=1>CN(C)C=O>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[CH:15]([CH2:16][CH2:17][CH3:18])[CH2:14][N:13]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:12][CH:11]2[O:26][CH2:28][C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 703202-BromomethylnaphthaleneHCID 86604427tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-hydroxy-5-propyl-piperidine-1-carboxylate

생성물 1

HCID 86604425tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-naphthalen-2-ylmethoxy-5-propyl-piperidine-1-carboxylate수율 77.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

37 mg (0.85 mmol) of sodium hydride (55% dispersion in refined oil) were added to a solution of 200 mg (0.56 mmol) of tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-hydroxy-5-propyl-piperidine-1-carboxylate and 188 mg (0.85 mmol) of 2-bromomethylnaphthalene in 10 ml of dimethylformamide and the reaction mixture was stirred at room temperature for 5 hours. For the working-up, the reaction mixture was evaporated in an oil pump vacuum, the residue was partitioned between water and ether and thereafter the separated aqueous phase was extracted five times with 50 ml of ether each time. The combined ether extracts were washed with saturated sodium chloride solution, dried over sodium sulphate and evaporated under reduced pressure. For purification, the crude product was chromatographed on silica gel using a 96:4 mixture of toluene and ethyl acetate as the eluent. There were obtained 215 mg (77% of theory) of tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-naphthalen-2-ylmethoxy-5-propyl-piperidine-1-carboxylate as a colourless oil; MS: 494 (M+H)+.

후처리

  1. customthe reaction mixture was evaporated in an oil pump vacuum
  2. customthe residue was partitioned between water and ether
  3. extractionthe separated aqueous phase was extracted five times with 50 ml of ether each time
  4. washThe combined ether extracts were washed with saturated sodium chloride solution
  5. dry with materialdried over sodium sulphate
  6. customevaporated under reduced pressure
  7. customFor purification
  8. customthe crude product was chromatographed on silica gel using
  9. additiona 96:4 mixture of toluene and ethyl acetate as the eluent

출처 및 근거

ORD 기록
ord-e4d3aa28a6654190a7df9ee2ebc9d2c8
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06150526

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