8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone

HRID 1858937

반응식

HRID 1858937 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([OH:19])[CH2:18][CH2:17][C:12]3(OCC[O:13]3)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8]>CC(C)=O.Cl>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([OH:19])[CH2:10][CH2:11][C:12](=[O:13])[CH2:17][CH2:18]2)[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

4

반응물 1

HCID 221221048-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

생성물 1

HCID 221220904-(3,4-Difluorophenyl)-4-hydroxycyclohexanone수율 48%

시약·촉매·용매 2

HCID 180Acetone용매HCID 313Hydrochloric Acid용매

실험 절차

A solution of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol (3 mmole) in acetone (100 ml) and concentrated HCl (1 ml) was reacted as described in example 25 to give the product (48%, mp: 84-85° C.). Calc'd for C12H12F2O2 : C, 63.72%; H, 5.35%. Found: C, 62.72%; H, 5.24%.

출처 및 근거

ORD 기록
ord-5900ea93f44047e7ac464e409abfa657
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06153611

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