Hydrogen Peroxide → 3'-Phenylspiro[indene-2,2'-oxirane]-1,3-dione

HRID 1859078

반응식

HRID 1859078 반응식
[CH:1](=[C:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:19]O.[OH-].[Na+].O>CO>[C:2]1([CH:1]2[C:8]3([C:9](=[O:18])[C:10]4[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=4)[C:16]3=[O:17])[O:19]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 2378222-Benzylidene-1,3-indandione

생성물 1

HCID 31422143'-Phenylspiro[indene-2,2'-oxirane]-1,3-dione

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
5 °C

실험 절차

To a suspension of 2-benzylidene-1,3-indandione (20 g) in methanol (200 ml) was added 30% hydrogen peroxide (19 ml). The suspension was cooled to 5° C. and 1 N sodium hydroxide (2.1 ml) was added dropwise at such a rate as to keep the temperature below 15 ° C. After completed addition, stirring was continued at room temperature for 30 minutes. The mixture was then poured into water (1.2 L). The resulting crystalline precipitate was collected by filtration, washed on the filter with water (3×100 ml) and dried under high vacuum at room temperature for 24 hours, affording 3-phenylspiro[oxirane-2,2'-indan]-1',3'-dione as a yellow solid (17 g).

후처리

  1. customthe temperature below 15 ° C
  2. additionaddition
  3. filtrationThe resulting crystalline precipitate was collected by filtration
  4. washwashed on the
  5. filtrationfilter with water (3×100 ml)
  6. customdried under high vacuum at room temperature for 24 hours

출처 및 근거

ORD 기록
ord-f5e821a3172d4116a7e7d12c233b35ab
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06153645

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