3-Amino-4-methoxybenzanilide → 3-(2,4-Difluoro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide

HRID 1859741

반응식

HRID 1859741 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH2:13][C:14]1[CH:15]=[C:16]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18]>N1C=CC=CC=1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([NH:13][C:14]1[CH:15]=[C:16]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18])(=[O:11])=[O:10]

참가 물질

4

반응물 2

HCID 84263-Amino-4-methoxybenzanilideHCID 27342732,4-Difluorobenzenesulfonyl Chloride

생성물 1

HCID 186262623-(2,4-Difluoro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide수율 84.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Prepared according to the procedure described for Example 121 using 2,4-difluorobenzenesulfonyl chloride (2.19 g, 10 mmol), 3-amino-4-methoxy-N-phenyl-benzamide (2.43 g, 10 mmol), and pyridine (25 mL) to afford the product (3.532 g); m.p. 198-200° C. after trituration in hexanes/ethyl acetate (1:1).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-8e0a43a66efd4394b446b0f70e7fd65c
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528528B2

연결된 노트

불러오는 중…