Sodium Hydroxide → HCID 10412670, 화합물

HRID 1859872노트

반응식

HRID 1859872 반응식
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36][CH3:37])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36][CH3:37])=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 18625856Ethyl 2-butyl-3-[4-[2-(2'-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

생성물 1

HCID 10412670HCID 10412670, 화합물수율 88.2%

실험 절차

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2′-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (750 mg), which is the product of Example 42, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (625 mg) as a pale orange powder.

후처리

  1. additionthe reaction mixture was treated

출처 및 근거

ORD 기록
ord-97c3b30546c544389ac699f3cada0a0c
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

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