Sodium Hydroxide → 3-[4-[2-(Biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionic acid

HRID 1859939노트

반응식

HRID 1859939 반응식
[C:1]1([C:7]2[CH:36]=[CH:35][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([N:30]4[CH:34]=[CH:33][CH:32]=[CH:31]4)[C:25]([O:27]CC)=[O:26])=[CH:19][CH:18]=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:8]=[CH:9][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([N:30]3[CH:34]=[CH:33][CH:32]=[CH:31]3)[C:25]([OH:27])=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:35][CH:36]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 18625789Ethyl 3-[4-[2-(4-phenylbenzoylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionate

생성물 1

HCID 186259593-[4-[2-(Biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Ethyl 3-[4-[2-(4-phenylbenzoylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionate, which is the product of Example 193, is hydrolyzed by sodium hydroxide in methanol to give the title compound.

출처 및 근거

ORD 기록
ord-5ffba238a711439bb32b36dda0dab40a
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

반응 노트

불러오는 중…