2,2,3,3-Tetrafluoro-1-propanol → Methyl 6-(2,2,3,3-tetrafluoropropoxy)-3-pyridinecarboxylate

HRID 1860038노트

반응식

HRID 1860038 반응식
[F:1][C:2]([F:8])([CH:5]([F:7])[F:6])[CH2:3][OH:4].[H-].[Na+].Cl[C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][N:13]=1>>[F:1][C:2]([F:8])([CH:5]([F:7])[F:6])[CH2:3][O:4][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][N:13]=1

참가 물질

4

반응물 3

HCID 64412,2,3,3-Tetrafluoro-1-propanolHCID 24758Sodium hydrideHCID 254249Methyl 6-chloropyridine-3-carboxylate

생성물 1

HCID 18625872Methyl 6-(2,2,3,3-tetrafluoropropoxy)-3-pyridinecarboxylate

실험 절차

In a similar manner to that described in Reference example 1(c), a reaction was carried out using 2,2,3,3-tetrafluoropropanol (5.23 ml), sodium hydride (55% suspension in oil, 1.91 g) and methyl 6-chloronicotinate (5.00 g) and treated to afford crude methyl 6-(2,2,3,3-tetrafluoropropoxy)nicotinate (5.42 g) as a colorless oil. In a similar manner to that described in Example 2, a reaction was carried out using the crude product described above (2.70 g) and aqueous sodium hydroxide solution (2N, 15 ml) and the reaction mixture was treated to afford crude title compound (1.60 g). This product was used in Example 102 and Example 150 without further purification.

후처리

  1. additiontreated

출처 및 근거

ORD 기록
ord-09e3c86cfe4e43be886c3c0c3d5342f6
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

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