2-Amino-4-methylpyridine → N-(4-Methyl-2-pyridyl)acetamide

HRID 1860390

반응식

HRID 1860390 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>C(O)(=O)C>[C:9]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)(=[O:11])[CH3:10]

참가 물질

4

반응물 2

HCID 15332-Amino-4-methylpyridineHCID 7918Acetic Anhydride

생성물 1

HCID 220485N-(4-Methyl-2-pyridyl)acetamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2-amino-4-methylpyridine (20 g) in acetic acid (80 ml) was added acetic anhydride and the resulting solution was refluxed for 3 h. The solution was concentrated in vacuo and the solid obtained was triturated with about 50 ml of water and carefully neutralised with solid sodium bicarbonate. The solid was filtered, washed with water and dried under vacuum to give the crude title compound as a white solid (20 g).

후처리

  1. temperaturethe resulting solution was refluxed for 3 h
  2. concentrationThe solution was concentrated in vacuo
  3. customthe solid obtained
  4. customwas triturated with about 50 ml of water
  5. filtrationThe solid was filtered
  6. washwashed with water
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-363bc9926a5c42c3a799942f32be0d9c
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06531466B2

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