Water → 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid

HRID 1860875

반응식

HRID 1860875 반응식
C([O:3][C:4]([C:6]1[C:10]([CH2:11][CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])=[C:9]([CH:17]=[O:18])[NH:8][C:7]=1[CH3:19])=[O:5])C.[OH-].[Na+].O>CO.CCOC(C)=O>[CH3:16][N:14]([CH3:15])[CH2:13][CH2:12][CH2:11][C:10]1[C:6]([C:4]([OH:5])=[O:3])=[C:7]([CH3:19])[NH:8][C:9]=1[CH:17]=[O:18]

참가 물질

6

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 542399104-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

생성물 1

HCID 225710744-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid수율 94%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (300 mg, 1.13 mmol) and sodium hydroxide in MeOH (4 mL)/water (2 mL) was stirred at 80° C. for 19 hr. The reaction was then diluted with EtOAc. The aqueous layer was separated, neutralized and concentrated. The residue was dissolved in MeOH, filtered and the filtrate was concentrated to give 251 mg (94%) of 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid.

후처리

  1. customThe aqueous layer was separated
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in MeOH
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-cbebf8a6be8546749247328f611865ed
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06531502B1

연결된 노트

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