Water → Ergosterol, acetate

HRID 1862550노트

반응식

HRID 1862550 반응식
[CH3:1][C@@H:2]([C@@H:10]1[C@@:14]2([CH3:29])[CH2:15][CH2:16][C@@H:17]3[C@@:22]4([CH3:28])[CH2:23][CH2:24][C@H:25]([OH:27])[CH2:26][C:21]4=[CH:20][CH:19]=[C:18]3[C@@H:13]2[CH2:12][CH2:11]1)/[CH:3]=[CH:4]/[C@@H:5]([CH:7]([CH3:9])[CH3:8])[CH3:6].[C:30](OC(=O)C)(=[O:32])[CH3:31].O>N1C=CC=CC=1>[C:30]([O:27][C@H:25]1[CH2:24][CH2:23][C@@:22]2([CH3:28])[C:21](=[CH:20][CH:19]=[C:18]3[C@@H:17]2[CH2:16][CH2:15][C@@:14]2([CH3:29])[C@H:13]3[CH2:12][CH2:11][C@@H:10]2[C@H:2]([CH3:1])/[CH:3]=[CH:4]/[C@H:5]([CH3:6])[CH:7]([CH3:8])[CH3:9])[CH2:26]1)(=[O:32])[CH3:31]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 444679Ergosterol

생성물 1

HCID 6436903Ergosterol, acetate수율 74%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 50 gm (0.13 mol) of ergosterol (1) in 300 mL of anhydrous pyridine was added 33.3 mL (0.35 mol) of acetic anhydride. The mixture was stirred at room temperature overnight and then 600 mL of water was added. The precipitate was filtered and washed three times with 200 mL portions of acetonitrile and then air dried to yield 42.0 g (74%) of (2).

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed three times with 200 mL portions of acetonitrile
  3. customair dried

출처 및 근거

ORD 기록
ord-087be7b33c154d15bef47192ea7389b1
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538037B2

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